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Principal Scientist, Pharmacology


Werewolf Therapeutics is an exciting, newly public, biotherapeutics company located in the heart of the Watertown biotech hub, focusing on the development of novel biologic agents targeting immune regulatory pathways for the treatment of cancer


The successful candidate will be a creative scientist with strong problem-solving skills and demonstrated experience in in vivo biotherapeutics pharmacology. They will provide expertise and leadership for in vivo pharmacology studies to test and evaluate novel tumor-directed and immuno-oncology-focused therapeutics. They will independently plan and manage in vivo experiments in syngeneic, PDX and humanized mouse models through close collaboration and interaction with specialized external CRO. The successful candidate will present the data to the project team and senior management. They will be expected to thrive in a dynamic start-up environment.


Reasonable Accommodations Statement

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


  • Independently design and plan syngeneic mouse pharmacology studies with a focus on anti-tumor activity, PK/PD relationship, MOA and biomarker identification.
  • All in vivo studies will be performed by external CRO or in an external mouse vivarium hotel set-up.
  • Analyze various mouse and NHP plasma and tumor samples to answer PK, PD, MOA, and biomarker questions (hands-on bench work).
  • Utilize various cell-based and biochemical assay for sample analysis (ELISA, AlphaLISA, Luminex, Jess (Protein simple) protein analysis, cell-based activity, proliferation assays and various other platforms.
  • Advise translational team on selection and use of various syngeneic mouse models to answer critical project questions.
  • Use external CRO resources to develop, troubleshoot and execute in vivo studies.
  • Perform statistical analysis of experimental data from in vitro and in vivo studies.
  • Maintain detailed and well-organized electronic lab notebook.
  • Actively participate in presentations of lab data and scientific discussions in lab meetings.
  • Other duties as may be required.



  • A Ph.D. in Cell or Cancer Biology, Pharmacology, Immunology, or related disciplines.

Experience and Requirements:  

  • 5+ years of industrial or postdoctoral laboratory experience working in a cancer, immunology, or bioanalytical laboratory.
  • Extensive technical and hands-on experience with mouse syngeneic tumor models and PK/PD studies (i.v., i.p, s.c. and oral).
  • Strong expertise in cellular tumor immunology, immune checkpoints and T cell/NK biology is a plus.
  • Prior expertise with managing work and timelines at various CRO is a must.
  • Strong analytical and data analysis skills are required.
  • Excellent problem-solving skills for developing creative solutions and for maintaining timelines with strong organizational skills.
  • Strong written and oral communication skills are a must. Demonstrated ability to work as part of a team to execute experimental plans and deliver results is also necessary.

Computer Skills: 

  • Expertise with data processing and analysis tools, Word, Excel, PowerPoint, and Prism.


  • Work is normally performed in a typical interior/office/lab work environment.
  • None or very limited physical effort required.
  • Work environment involves some exposure to hazards or physical risk, which require following basic safety precautions.


For further information or to be considered for this position, please

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